Host EPAC1 Modulates Rickettsial Adhesion to Vascular Endothelial Cells via Regulation of ANXA2 Y23 Phosphorylation

Host EPAC1 Modulates Rickettsial Adhesion to Vascular Endothelial Cells via Regulation of ANXA2 Y23 Phosphorylation

Introduction: Intracellular cAMP receptor exchange proteins directly activated by cAMP 1 (<i>EPAC1</i>) regulate obligate intracellular parasitic bacterium rickettsial adherence to and invasion into vascular endothelial cells (ECs). However, underlying precise mechanism(s) remain unclear...

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Bibliographic Details
Main Authors: Zhengchen Su, Thomas R. Shelite, Yuan Qiu, Qing Chang, Maki Wakamiya, Jiani Bei, Xi He, Changcheng Zhou, Yakun Liu, Emmanuel Nyong, Yuejin Liang, Angelo Gaitas, Tais B. Saito, Bin Gong
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Pathogens
Subjects:
bacterial adhesion
rickettsia
endothelial cell
<i>EPAC1</i>
annexin A2
fluidic force microscopy
Online Access:https://www.mdpi.com/2076-0817/10/10/1307

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https://www.mdpi.com/2076-0817/10/10/1307

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