3α,7-Dihydroxy-14(13→12)<i>abeo</i>-5β,12α(H),13β(H)-cholan-24-oic Acids Display Neuroprotective Properties in Common Forms of Parkinson’s Disease

3α,7-Dihydroxy-14(13→12)<i>abeo</i>-5β,12α(H),13β(H)-cholan-24-oic Acids Display Neuroprotective Properties in Common Forms of Parkinson’s Disease

Parkinson’s Disease is the most common neurodegenerative movement disorder globally, with prevalence increasing. There is an urgent need for new therapeutics which are disease-modifying rather than symptomatic. Mitochondrial dysfunction is a well-documented mechanism in both sporadic and familial Pa...

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Bibliographic Details
Main Authors: Andreas Luxenburger, Hannah Clemmens, Christopher Hastings, Lawrence D. Harris, Elizabeth M. Ure, Scott A. Cameron, Jan Aasly, Oliver Bandmann, Alex Weymouth-Wilson, Richard H. Furneaux, Heather Mortiboys
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomolecules
Subjects:
bile acids
C-<i>nor</i>-D-<i>homo</i> bile acids
rearrangement
drug discovery
neurodegenerative diseases
Parkinson’s Disease
Online Access:https://www.mdpi.com/2218-273X/13/1/76

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https://www.mdpi.com/2218-273X/13/1/76

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