Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1

Hypoxia-induced P4HA1 overexpression promotes post-ischemic angiogenesis by enhancing endothelial glycolysis through downregulating FBP1

Abstract Background Angiogenesis is essential for tissue repair in ischemic diseases, relying on glycolysis as its primary energy source. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1), the catalytic subunit of collagen prolyl 4-hydroxylase, is a glycolysis-related gene in cancers. However, its role i...

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Bibliographic Details
Main Authors: Yating Xu, Di Xia, Kai Huang, Minglu Liang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Journal of Translational Medicine
Subjects:
P4HA1
α-Ketoglutarate
TET2-FBP1 pathway
Glycolysis
Angiogenesis
Online Access:https://doi.org/10.1186/s12967-024-04872-x

Internet

https://doi.org/10.1186/s12967-024-04872-x

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