Loading and Release of Phenolic Compounds Present in Mexican Oregano (<i>Lippia graveolens</i>) in Different Chitosan Bio-Polymeric Cationic Matrixes
Mexican oregano (<i>Lippia graveolens</i>) polyphenols have antioxidant and anti-inflammatory potential, but low bioaccessibility. Therefore, in the present work the micro/nano-encapsulation of these compounds in two different matrixes of chitosan (CS) and chitosan-<i>b</i>-p...
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| Format: | Article |
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MDPI AG
2022-09-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/14/17/3609 |
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| author | Melissa Garcia-Carrasco Lorenzo A. Picos-Corrales Erick P. Gutiérrez-Grijalva Miguel A. Angulo-Escalante Angel Licea-Claverie J. Basilio Heredia |
| author_facet | Melissa Garcia-Carrasco Lorenzo A. Picos-Corrales Erick P. Gutiérrez-Grijalva Miguel A. Angulo-Escalante Angel Licea-Claverie J. Basilio Heredia |
| author_sort | Melissa Garcia-Carrasco |
| collection | DOAJ |
| description | Mexican oregano (<i>Lippia graveolens</i>) polyphenols have antioxidant and anti-inflammatory potential, but low bioaccessibility. Therefore, in the present work the micro/nano-encapsulation of these compounds in two different matrixes of chitosan (CS) and chitosan-<i>b</i>-poly(PEGMA<sub>2000</sub>) (CS-<i>b</i>-PPEGMA) is described and assessed. The particle sizes of matrixes of CS (~955 nm) and CS-<i>b</i>-PPEGMA (~190 nm) increased by 10% and 50%, respectively, when the phenolic compounds were encapsulated, yielding loading efficiencies (LE) between 90–99% and 50–60%, correspondingly. The release profiles in simulated fluids revealed a better control of host–guest interactions by using the CS-<i>b</i>-PPEGMA matrix, reaching phenolic compounds release of 80% after 24 h, while single CS retained the guest compounds. The total reducing capacity (TRC) and Trolox equivalent antioxidant capacity (TEAC) of the phenolic compounds (PPHs) are protected and increased (more than five times) when they are encapsulated. Thus, this investigation provides a standard encapsulation strategy and relevant results regarding nutraceuticals stabilization and their improved bioaccessibility. |
| first_indexed | 2024-03-10T01:20:37Z |
| format | Article |
| id | doaj.art-10fbd7ad0f7e47cebd6407bc6aed9361 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T01:20:37Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-10fbd7ad0f7e47cebd6407bc6aed93612023-11-23T13:59:46ZengMDPI AGPolymers2073-43602022-09-011417360910.3390/polym14173609Loading and Release of Phenolic Compounds Present in Mexican Oregano (<i>Lippia graveolens</i>) in Different Chitosan Bio-Polymeric Cationic MatrixesMelissa Garcia-Carrasco0Lorenzo A. Picos-Corrales1Erick P. Gutiérrez-Grijalva2Miguel A. Angulo-Escalante3Angel Licea-Claverie4J. Basilio Heredia5Nutraceuticals and Functional Foods Laboratory, Centro de Investigación en Alimentación y Desarrollo, A.C., Carretera a Eldorado Km. 5.5, Col. Campo El Diez, Culiacán 80110, Sinaloa, MexicoFacultad de Ingeniería Culiacán, Universidad Autónoma de Sinaloa, Ciudad Universitaria, Culiacán 80013, Sinaloa, MexicoCátedras CONACYT-Centro de Investigación en Alimentación y Desarrollo, A.C., Carretera a Eldorado Km. 5.5, Col. Campo El Diez, Culiacán 80110, Sinaloa, MexicoNutraceuticals and Functional Foods Laboratory, Centro de Investigación en Alimentación y Desarrollo, A.C., Carretera a Eldorado Km. 5.5, Col. Campo El Diez, Culiacán 80110, Sinaloa, MexicoCentro de Graduados e Investigación en Química, Tecnológico Nacional de Mexico/Instituto Tecnológico de Tijuana, A.P. 1166, Tijuana 22000, Baja California, MexicoNutraceuticals and Functional Foods Laboratory, Centro de Investigación en Alimentación y Desarrollo, A.C., Carretera a Eldorado Km. 5.5, Col. Campo El Diez, Culiacán 80110, Sinaloa, MexicoMexican oregano (<i>Lippia graveolens</i>) polyphenols have antioxidant and anti-inflammatory potential, but low bioaccessibility. Therefore, in the present work the micro/nano-encapsulation of these compounds in two different matrixes of chitosan (CS) and chitosan-<i>b</i>-poly(PEGMA<sub>2000</sub>) (CS-<i>b</i>-PPEGMA) is described and assessed. The particle sizes of matrixes of CS (~955 nm) and CS-<i>b</i>-PPEGMA (~190 nm) increased by 10% and 50%, respectively, when the phenolic compounds were encapsulated, yielding loading efficiencies (LE) between 90–99% and 50–60%, correspondingly. The release profiles in simulated fluids revealed a better control of host–guest interactions by using the CS-<i>b</i>-PPEGMA matrix, reaching phenolic compounds release of 80% after 24 h, while single CS retained the guest compounds. The total reducing capacity (TRC) and Trolox equivalent antioxidant capacity (TEAC) of the phenolic compounds (PPHs) are protected and increased (more than five times) when they are encapsulated. Thus, this investigation provides a standard encapsulation strategy and relevant results regarding nutraceuticals stabilization and their improved bioaccessibility.https://www.mdpi.com/2073-4360/14/17/3609chitosanpolyethylene glycol methacrylateoreganophenolic compoundsnanoencapsulationbioaccessibility |
| spellingShingle | Melissa Garcia-Carrasco Lorenzo A. Picos-Corrales Erick P. Gutiérrez-Grijalva Miguel A. Angulo-Escalante Angel Licea-Claverie J. Basilio Heredia Loading and Release of Phenolic Compounds Present in Mexican Oregano (<i>Lippia graveolens</i>) in Different Chitosan Bio-Polymeric Cationic Matrixes Polymers chitosan polyethylene glycol methacrylate oregano phenolic compounds nanoencapsulation bioaccessibility |
| title | Loading and Release of Phenolic Compounds Present in Mexican Oregano (<i>Lippia graveolens</i>) in Different Chitosan Bio-Polymeric Cationic Matrixes |
| title_full | Loading and Release of Phenolic Compounds Present in Mexican Oregano (<i>Lippia graveolens</i>) in Different Chitosan Bio-Polymeric Cationic Matrixes |
| title_fullStr | Loading and Release of Phenolic Compounds Present in Mexican Oregano (<i>Lippia graveolens</i>) in Different Chitosan Bio-Polymeric Cationic Matrixes |
| title_full_unstemmed | Loading and Release of Phenolic Compounds Present in Mexican Oregano (<i>Lippia graveolens</i>) in Different Chitosan Bio-Polymeric Cationic Matrixes |
| title_short | Loading and Release of Phenolic Compounds Present in Mexican Oregano (<i>Lippia graveolens</i>) in Different Chitosan Bio-Polymeric Cationic Matrixes |
| title_sort | loading and release of phenolic compounds present in mexican oregano i lippia graveolens i in different chitosan bio polymeric cationic matrixes |
| topic | chitosan polyethylene glycol methacrylate oregano phenolic compounds nanoencapsulation bioaccessibility |
| url | https://www.mdpi.com/2073-4360/14/17/3609 |
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