Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects

Synthesis of New Proteomimetic Quinazolinone Alkaloids and Evaluation of Their Neuroprotective and Antitumor Effects

New quinazolinone derivatives of the marine-derived alkaloids fiscalin B (<b>3</b>) and fumiquinazoline G (<b>1</b>), with neuroprotective and antitumor effects, were synthesized. Eleven quinazolinone-containing indole alkaloids were synthesized, proceeding the <i>anti&...

Full description

Bibliographic Details
Main Authors: Solida Long, Diana I. S. P. Resende, Anake Kijjoa, Artur M. S. Silva, Ricardo Fernandes, Cristina P. R. Xavier, M. Helena Vasconcelos, Emília Sousa, Madalena M. M. Pinto
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Molecules
Subjects:
antitumor
neuroprotection
quinazolinones
fiscalin B
fumiquinazoline
enantioselectivity
Online Access:https://www.mdpi.com/1420-3049/24/3/534

Internet

https://www.mdpi.com/1420-3049/24/3/534

Similar Items