Surface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo pharmacokinetic assessment

Surface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo pharmacokinetic assessment

Vinpocetine (VNP), a semisynthetic active pharmaceutical ingredient, is used for oral management of cerebrovascular diseases because of its ability to enhance the blood flow to the brain. However, despite that, the therapeutic application of VNP is restricted due to its reduced bioavailability and d...

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Bibliographic Details
Main Authors: Hibah M. Aldawsari, Shaimaa M. Badr-Eldin, Nourah Y. Assiri, Nabil A. Alhakamy, Anna Privitera, Filippo Caraci, Giuseppe Caruso
Format: Article
Language:English
Published: Taylor & Francis Group 2022-08-01
Series:Drug Delivery
Subjects:
Vinpocetine
surface-tailored intranasal emulsomes
cationization
PEGylation
pharmacokinetics
brain delivery
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2022.2110996

Internet

https://www.tandfonline.com/doi/10.1080/10717544.2022.2110996

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