A randomized pharmacological fMRI trial investigating d-cycloserine and brain plasticity mechanisms in learned pain responses

Abstract Learning and negative outcome expectations can increase pain sensitivity, a phenomenon known as nocebo hyperalgesia. Here, we examined how a targeted pharmacological manipulation of learning would impact nocebo responses and their brain correlates. Participants received either a placebo (n ...

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Bibliographic Details
Main Authors: Mia A. Thomaidou, Joseph S. Blythe, Dieuwke S. Veldhuijzen, Kaya J. Peerdeman, Johan (Hans) P. A. van Lennep, Erik J. Giltay, Henk R. Cremers, Andrea W. M. Evers
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23769-7