Inhibition of NKCC1 Modulates Alveolar Fluid Clearance and Inflammation in Ischemia-Reperfusion Lung Injury via TRAF6-Mediated Pathways

Inhibition of NKCC1 Modulates Alveolar Fluid Clearance and Inflammation in Ischemia-Reperfusion Lung Injury via TRAF6-Mediated Pathways

Background: The expression of Na-K-2Cl cotransporter 1 (NKCC1) in the alveolar epithelium is responsible for fluid homeostasis in acute lung injury (ALI). Increasing evidence suggests that NKCC1 is associated with inflammation in ALI. We hypothesized that inhibiting NKCC1 would attenuate ALI after i...

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Bibliographic Details
Main Authors: Chih-Hao Shen, Jr-Yu Lin, Yung-Lung Chang, Shu-Yu Wu, Chung-Kan Peng, Chin-Pyng Wu, Kun-Lun Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
Na-K-2Cl cotransporter 1
bumetanide
ischemia-reperfusion
acute lung injury
epithelial sodium channel
p38 mitogen-activated protein kinase
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02049/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02049/full

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