Salvianolic acid B activates chondrocytes autophagy and reduces chondrocyte apoptosis in obese mice via the KCNQ1OT1/miR-128-3p/SIRT1 signaling pathways

Salvianolic acid B activates chondrocytes autophagy and reduces chondrocyte apoptosis in obese mice via the KCNQ1OT1/miR-128-3p/SIRT1 signaling pathways

Abstract Purpose Salvianolic acid B (Sal B) possesses strong anti-inflammatory and antioxidant activity. This study aims to explore the underlying mechanism of Sal B to improve the obesity-related osteoarthritis (OA). Methods C57BL/6 J male mice were fed with a normal control diet (NCD), a high fat...

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Bibliographic Details
Main Authors: Tianwen Sun, Fei Wang, Gaojian Hu, Zhizhou Li
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Nutrition & Metabolism
Subjects:
Salvianolic acid B
KCNQ1OT1
Obesity
Autophagy
Osteoarthritis
Online Access:https://doi.org/10.1186/s12986-022-00686-0

Internet

https://doi.org/10.1186/s12986-022-00686-0

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