Robust cone-mediated signaling persists late into rod photoreceptor degeneration

Rod photoreceptor degeneration causes deterioration in the morphology and physiology of cone photoreceptors along with changes in retinal circuits. These changes could diminish visual signaling at cone-mediated light levels, thereby limiting the efficacy of treatments such as gene therapy for rescui...

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Bibliographic Details
Main Authors: Miranda L Scalabrino, Mishek Thapa, Lindsey A Chew, Esther Zhang, Jason Xu, Alapakkam P Sampath, Jeannie Chen, Greg D Field
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/80271