Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling

Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling

Abstract Transmembrane of coiled-coil domains 1 (TMCO1) plays an important role in maintaining homeostasis of calcium (Ca2+) stores in the endoplasmic reticulum (ER). TMCO1-defect syndrome shares multiple features with human cerebro-facio-thoracic (CFT) dysplasia, including abnormal corpus callosum...

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Main Authors: Ke-Yan Yang, Song Zhao, Haiping Feng, Jiaqi Shen, Yuwei Chen, Si-Tong Wang, Si-Jia Wang, Yu-Xin Zhang, Yun Wang, Caixia Guo, Hongmei Liu, Tie-Shan Tang
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05131-x

Internet

https://doi.org/10.1038/s41419-022-05131-x

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