Biotransformation of hydroxychloroquine to evaluate the cytotoxicity of its metabolites and mimic mammalian metabolism

Biotransformation of hydroxychloroquine to evaluate the cytotoxicity of its metabolites and mimic mammalian metabolism

Hydroxychloroquine (HCQ) displays attractive anti-inflammatory and antiviral effects. Because of that, such a drug made part of some clinical trials for combating Sars-CoV-2 during the COVID-19 pandemic. The present study aimed to conduct the biotransformation of HCQ by filamentous fungi reported as...

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Bibliographic Details
Main Authors: Valmore Henrique Pereira dos Santos, Wanderleya Toledo dos Santos, Marisa Ionta, Ana Cláudia Chagas de Paula, Eliane de Oliveira Silva
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Results in Chemistry
Subjects:
Hydroxychloroquine
Fungal biotransformation
Cytotoxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622004805

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http://www.sciencedirect.com/science/article/pii/S2211715622004805

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