NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses

NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses

Chronic stress can produce reward system deficits (i.e., anhedonia) and other common symptoms associated with depressive disorders, as well as neural circuit hypofunction in the medial prefrontal cortex (mPFC). However, the molecular mechanisms by which chronic stress promotes depressive-like behavi...

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Bibliographic Details
Main Authors: Brandon W Hughes, Benjamin M Siemsen, Evgeny Tsvetkov, Stefano Berto, Jaswinder Kumar, Rebecca G Cornbrooks, Rose Marie Akiki, Jennifer Y Cho, Jordan S Carter, Kirsten K Snyder, Ahlem Assali, Michael D Scofield, Christopher W Cowan, Makoto Taniguchi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
Anhedonia
hypofrontality
chronic social defeat stress
prefrontal cortex
NPAS4
RNA-sequencing
Online Access:https://elifesciences.org/articles/75631

Internet

https://elifesciences.org/articles/75631

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