Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase

Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase

ABSTRACT In Neurospora crassa, caffeine and other methylxanthines are known to inhibit phosphodiesterase (PDE) activity, leading to augmented cAMP levels. In this organism, it has also been shown that the addition of these drugs significantly lengthens the circadian period, as seen by conidiation rh...

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Bibliographic Details
Main Authors: Consuelo Olivares-Yañez, María P. Alessandri, Loreto Salas, Luis F. Larrondo
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:Microbiology Spectrum
Subjects:
methylxanthines
circadian clock
phosphodiesterase
cAMP
protein kinase A
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03727-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03727-22

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