Use of Bulk Segregant Analysis for Determining the Genetic Basis of Azole Resistance in the Opportunistic Pathogen Aspergillus fumigatus

Use of Bulk Segregant Analysis for Determining the Genetic Basis of Azole Resistance in the Opportunistic Pathogen Aspergillus fumigatus

A sexual cycle was described in 2009 for the opportunistic fungal pathogen Aspergillus fumigatus, opening up for the first time the possibility of using techniques reliant on sexual crossing for genetic analysis. The present study was undertaken to evaluate whether the technique ‘bulk segregant anal...

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Bibliographic Details
Main Authors: George D. Ashton, Fei Sang, Martin Blythe, Daniel Zadik, Nadine Holmes, Sunir Malla, Simone M. T. Camps, Victoria Wright, Willem J. G. Melchers, Paul E. Verweij, Paul S. Dyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
antifungal
itraconazole
genomics
filamentous fungi
next-generation sequencing
CYP51
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.841138/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.841138/full

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