Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein

Protease-Sensitive and -Resistant Forms of Human and Murine Alpha-Synucleins in Distinct Brain Regions of Transgenic Mice (M83) Expressing the Human Mutated A53T Protein

Human neurodegenerative diseases associated with the misfolding of the alpha-synuclein (aS) protein (synucleinopathies) are similar to prion diseases to the extent that lesions are spread by similar molecular mechanisms. In a transgenic mouse model (M83) overexpressing a mutated (A53T) form of human...

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Bibliographic Details
Main Authors: Dominique Bétemps, Jean-Noël Arsac, Simon Nicot, Dominique Canal, Habiba Tlili, Maxime Belondrade, Eric Morignat, Jérémy Verchère, Damien Gaillard, Lilian Bruyère-Ostells, Charly Mayran, Latifa Lakhdar, Daisy Bougard, Thierry Baron
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biomolecules
Subjects:
α-synuclein
β-amyloid
Parkinson’s disease
Lewy Body Disease
PMCA
Online Access:https://www.mdpi.com/2218-273X/13/12/1788

Internet

https://www.mdpi.com/2218-273X/13/12/1788

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