CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease

CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease

IntroductionInflammatory cell infiltration is a novel hallmark of diabetic kidney disease (DKD), in part, by activated macrophages. Macrophage-to-tubular epithelial cell communication may play an important role in renal fibrosis. Circular RNAs (circRNAs) have been reported in the pathogenesis of var...

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Bibliographic Details
Main Authors: Ziyue Lin, Dan Lv, Xiaohui Liao, Rui Peng, Handeng Liu, Tianhui Wu, Keqian Wu, Yan Sun, Zheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Immunology
Subjects:
diabetic kidney disease
CircUBXN7
IGF2BP2
macrophage infiltration
epithelial-mesenchymal transition
tubulointerstitial fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1226962/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1226962/full

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