Cholinergic Signaling Attenuates Pro-Inflammatory Interleukin-8 Response in Colonic Epithelial Cells

Cholinergic Signaling Attenuates Pro-Inflammatory Interleukin-8 Response in Colonic Epithelial Cells

Infants affected by Hirschsprung disease (HSCR), a neurodevelopmental congenital disorder, lack ganglia of the intrinsic enteric nervous system (aganglionosis) in a variable length of the colon, and are prone to developing severe Hirschsprung-associated enterocolitis (HAEC). HSCR patients typically...

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Bibliographic Details
Main Authors: Isabelle Müller, Urs Kym, Virginie Galati, Sasha Tharakan, Ulrike Subotic, Thomas Krebs, Eleuthere Stathopoulos, Peter Schmittenbecher, Dietmar Cholewa, Philipp Romero, Bertram Reingruber, NIGStudy Group, Stefan Holland-Cunz, Simone Keck, Isabella Bielicki, Sandra Weih, Noëmi Zweifel, Kai-Uwe Kleitsch, Carole Gengler, Kiarasch Mortazawi, Milan Milosevic, Vera Otten, Lennart Homrighausen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
Hirschsprung disease
Hirschsprung-associated enterocolitis
intestinal epithelial cell
Interleukin-8
acetylcholine receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.781147/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.781147/full

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