Multidrug Intrinsic Resistance Factors in <named-content content-type="genus-species">Staphylococcus aureus</named-content> Identified by Profiling Fitness within High-Diversity Transposon Libraries

ABSTRACT Staphylococcus aureus is a leading cause of life-threatening infections worldwide. The MIC of an antibiotic against S. aureus, as well as other microbes, is determined by the affinity of the antibiotic for its target in addition to a complex interplay of many other cellular factors. Identif...

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Bibliographic Details
Main Authors: Mithila Rajagopal, Melissa J. Martin, Marina Santiago, Wonsik Lee, Veronica N. Kos, Tim Meredith, Michael S. Gilmore, Suzanne Walker
Format: Article
Language:English
Published: American Society for Microbiology 2016-09-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00950-16