The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation

The Effect of Wnt Pathway Modulators on Human iPSC-Derived Pancreatic Beta Cell Maturation

Current published protocols for targeted differentiation of human stem cells toward pancreatic β-cells fail to deliver sufficiently mature cells with functional properties comparable to human islet β-cells. We aimed to assess whether Wnt-modulation could promote the final protocol stages of β-cell m...

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Bibliographic Details
Main Authors: Heidrun Vethe, Luiza Ghila, Magnus Berle, Laurence Hoareau, Øystein A. Haaland, Hanne Scholz, Joao A. Paulo, Simona Chera, Helge Ræder
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Endocrinology
Subjects:
human induced pluripotent stem cell
β-like cells
Wnt signaling pathway
tankyrase inhibition
in vitro maturation
proteomics
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00293/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00293/full

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