Chronic unpredictable mild stress induces anxiety-like behavior in female C57BL/6N mice, accompanied by alterations in inflammation and the kynurenine pathway of tryptophan metabolism

Chronic unpredictable mild stress induces anxiety-like behavior in female C57BL/6N mice, accompanied by alterations in inflammation and the kynurenine pathway of tryptophan metabolism

Chronic stress can impact brain function through various mechanisms, contributing to the development of anxiety disorders. Chronic unpredictable mild stress (CUMS) is a well-established model for studying the effects of chronic stress. This study assessed the impacts of different durations of CUMS o...

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Bibliographic Details
Main Authors: Yanqin Luo, Ning Jiang, Yiwen Zhang, Yongzhi Zhao, Fang Chen, Xueyan Li, Meng Qiang, Guirong Zeng, Qinghu He, Xinmin Liu, Chunhui Shan
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Neuroscience
Subjects:
chronic unpredictable mild stress (CUMS)
anxiety
inflammation cytokines
kynurenine pathway
female
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1556744/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2025.1556744/full

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