Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal

Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal

Thimerosal has been widely used as a preservative in drug and vaccine products for decades. Due to the strong propensity to modify thiols in proteins, conformational changes could occur due to covalent bond formation between ethylmercury (a degradant of thimerosal) and thiols. Such a conformational...

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Bibliographic Details
Main Authors: Xiaofen Huang, Yike Li, Meifeng Nie, Mingxi Yue, Yufang Li, Zhijie Lin, Huirong Pan, Mujin Fang, Ting Wu, Shaowei Li, Jun Zhang, Ningshao Xia, Qinjian Zhao
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Thiol-modifying agent
Monoclonal antibody
Antigenicity loss
Epitope-specific
Conformational stability
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177920310479

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http://www.sciencedirect.com/science/article/pii/S2095177920310479

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