The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression

The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression

Cell type-specific gene expression is driven through the interplay between lineage-specific transcription factors (TFs) and the chromatin architecture, such as topologically associating domains (TADs), and enhancer-promoter interactions. To elucidate the molecular mechanisms of the cell fate decisio...

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Bibliographic Details
Main Authors: Kazuko Miyazaki, Masaki Miyazaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
lineage-specific transcription factor
chromatin architecture
enhancer
Rag1 and Rag2 gene
super-enhancer
3D genome organization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.659761/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.659761/full

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