The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression
Cell type-specific gene expression is driven through the interplay between lineage-specific transcription factors (TFs) and the chromatin architecture, such as topologically associating domains (TADs), and enhancer-promoter interactions. To elucidate the molecular mechanisms of the cell fate decisio...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-03-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.659761/full |
| _version_ | 1818878889167945728 |
|---|---|
| author | Kazuko Miyazaki Masaki Miyazaki |
| author_facet | Kazuko Miyazaki Masaki Miyazaki |
| author_sort | Kazuko Miyazaki |
| collection | DOAJ |
| description | Cell type-specific gene expression is driven through the interplay between lineage-specific transcription factors (TFs) and the chromatin architecture, such as topologically associating domains (TADs), and enhancer-promoter interactions. To elucidate the molecular mechanisms of the cell fate decisions and cell type-specific functions, it is important to understand the interplay between chromatin architectures and TFs. Among enhancers, super-enhancers (SEs) play key roles in establishing cell identity. Adaptive immunity depends on the RAG-mediated assembly of antigen recognition receptors. Hence, regulation of the Rag1 and Rag2 (Rag1/2) genes is a hallmark of adaptive lymphoid lineage commitment. Here, we review the current knowledge of 3D genome organization, SE formation, and Rag1/2 gene regulation during B cell and T cell differentiation. |
| first_indexed | 2024-12-19T14:21:21Z |
| format | Article |
| id | doaj.art-113cf3f22a134c7f8cb5dc3ec38221b7 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-19T14:21:21Z |
| publishDate | 2021-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-113cf3f22a134c7f8cb5dc3ec38221b72022-12-21T20:17:45ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-03-011210.3389/fimmu.2021.659761659761The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene ExpressionKazuko MiyazakiMasaki MiyazakiCell type-specific gene expression is driven through the interplay between lineage-specific transcription factors (TFs) and the chromatin architecture, such as topologically associating domains (TADs), and enhancer-promoter interactions. To elucidate the molecular mechanisms of the cell fate decisions and cell type-specific functions, it is important to understand the interplay between chromatin architectures and TFs. Among enhancers, super-enhancers (SEs) play key roles in establishing cell identity. Adaptive immunity depends on the RAG-mediated assembly of antigen recognition receptors. Hence, regulation of the Rag1 and Rag2 (Rag1/2) genes is a hallmark of adaptive lymphoid lineage commitment. Here, we review the current knowledge of 3D genome organization, SE formation, and Rag1/2 gene regulation during B cell and T cell differentiation.https://www.frontiersin.org/articles/10.3389/fimmu.2021.659761/fulllineage-specific transcription factorchromatin architectureenhancerRag1 and Rag2 genesuper-enhancer3D genome organization |
| spellingShingle | Kazuko Miyazaki Masaki Miyazaki The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression Frontiers in Immunology lineage-specific transcription factor chromatin architecture enhancer Rag1 and Rag2 gene super-enhancer 3D genome organization |
| title | The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression |
| title_full | The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression |
| title_fullStr | The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression |
| title_full_unstemmed | The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression |
| title_short | The Interplay Between Chromatin Architecture and Lineage-Specific Transcription Factors and the Regulation of Rag Gene Expression |
| title_sort | interplay between chromatin architecture and lineage specific transcription factors and the regulation of rag gene expression |
| topic | lineage-specific transcription factor chromatin architecture enhancer Rag1 and Rag2 gene super-enhancer 3D genome organization |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.659761/full |
| work_keys_str_mv | AT kazukomiyazaki theinterplaybetweenchromatinarchitectureandlineagespecifictranscriptionfactorsandtheregulationofraggeneexpression AT masakimiyazaki theinterplaybetweenchromatinarchitectureandlineagespecifictranscriptionfactorsandtheregulationofraggeneexpression AT kazukomiyazaki interplaybetweenchromatinarchitectureandlineagespecifictranscriptionfactorsandtheregulationofraggeneexpression AT masakimiyazaki interplaybetweenchromatinarchitectureandlineagespecifictranscriptionfactorsandtheregulationofraggeneexpression |