Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models

Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination in mouse models

Summary: Background: Vaccines in emergency use are efficacious against COVID-19, yet vaccine-induced prevention against nasal SARS-CoV-2 infection remains suboptimal. Methods: Since mucosal immunity is critical for nasal prevention, we investigated the efficacy of an intramuscular PD1-based recepto...

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Bibliographic Details
Main Authors: Runhong Zhou, Pui Wang, Yik-Chun Wong, Haoran Xu, Siu-Ying Lau, Li Liu, Bobo Wing-Yee Mok, Qiaoli Peng, Na Liu, Kin-Fai Woo, Shaofeng Deng, Rachel Chun-Yee Tam, Haode Huang, Anna Jinxia Zhang, Dongyan Zhou, Biao Zhou, Chun-Yin Chan, Zhenglong Du, Dawei Yang, Ka-Kit Au, Kwok-Yung Yuen, Honglin Chen, Zhiwei Chen
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:EBioMedicine
Subjects:
SARS-CoV-2
Receptor binding domain
Mucosal immunity
Nasal prevention
PD1-based DNA vaccine
Live-attenuated influenza-based vaccine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396421005569

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http://www.sciencedirect.com/science/article/pii/S2352396421005569

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