Methoxy-Substituted Tyramine Derivatives Synthesis, Computational Studies and Tyrosinase Inhibitory Kinetics

Methoxy-Substituted Tyramine Derivatives Synthesis, Computational Studies and Tyrosinase Inhibitory Kinetics

Targeting tyrosinase for melanogenesis disorders is an established strategy. Hydroxyl-substituted benzoic and cinnamic acid scaffolds were incorporated into new chemotypes that displayed in vitro inhibitory effects against mushroom and human tyrosinase for the purpose of identifying anti-melanogenic...

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Bibliographic Details
Main Authors: Yasir Nazir, Hummera Rafique, Naghmana Kausar, Qamar Abbas, Zaman Ashraf, Pornchai Rachtanapun, Kittisak Jantanasakulwong, Warintorn Ruksiriwanich
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
tyramine derivatives
tyrosinase inhibitors
inhibitory activity
enzyme kinetics mechanism
computational studies
Online Access:https://www.mdpi.com/1420-3049/26/9/2477

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https://www.mdpi.com/1420-3049/26/9/2477

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