15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma

15-Deoxy-Delta-12,14-Prostaglandin J2 Inhibits Lung Inflammation and Remodeling in Distinct Murine Models of Asthma

15-deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) has been described as an anti-inflammatory lipid mediator in several in vitro and in vivo studies, but its effect on allergic pulmonary inflammation remains elusive. The aim of this study was to investigate the therapeutic potential of 15d-PGJ2 based on d...

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Bibliographic Details
Main Authors: Diego S. Coutinho, Edna A. Anjos-Valotta, Caio V. M. F. do Nascimento, Ana Lucia A. Pires, Marcelo H. Napimoga, Vinícius F. Carvalho, Rafael C. Torres, Patrícia M. R. e Silva, Marco A. Martins
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
asthma
house dust mite
allergen
15d-PGJ2
lung inflammation
resolution
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00740/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00740/full

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