Destabilization of Heterologous Proteins Mediated by the GSK3β Phosphorylation Domain of the β-Catenin Protein

Destabilization of Heterologous Proteins Mediated by the GSK3β Phosphorylation Domain of the β-Catenin Protein

Background and Aims: Wnt/β-catenin signaling plays important roles in development and cellular processes. The hallmark of canonical Wnt signaling activation is the stabilization of β-catenin protein in cytoplasm and/or nucleus. The stability of β-catenin is the key to its biological functions and is...

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Bibliographic Details
Main Authors: Yuhan Kong, Hongyu Zhang, Xian Chen, Wenwen Zhang, Chen Zhao, Ning Wang, Ningning Wu, Yunfeng He, Guoxin Nan, Hongmei Zhang, Sheng Wen, Fang Deng, Zhan Liao, Di Wu, Junhui Zhang, Xinyue Qin, Rex C. Haydon, Hue H. Luu, Tong-Chuan He, Lan Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
β-catenin
Wnt signal
Protein degradation
Green fluorescent protein
Destabilized GFP
Chimeric proteins
Human cancer
Online Access:http://www.karger.com/Article/FullText/354518

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http://www.karger.com/Article/FullText/354518

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