Combinatorial hydrogels with biochemical gradients for screening 3D cellular microenvironments

Tools to investigate a wide range of 3D microenvironmental parameters are important for understanding and controlling cell fate. Here, the authors develop hydrogels with orthogonal biochemical gradients and use this screening system to identify microenvironments that induce mesenchymal stem cell cho...

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Bibliographic Details
Main Authors: Sebastián L. Vega, Mi Y. Kwon, Kwang Hoon Song, Chao Wang, Robert L. Mauck, Lin Han, Jason A. Burdick
Format: Article
Language:English
Published: Nature Portfolio 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03021-5