FEN1 upregulation mediated by SUMO2 via antagonizing proteasomal degradation promotes hepatocellular carcinoma stemness

FEN1 upregulation mediated by SUMO2 via antagonizing proteasomal degradation promotes hepatocellular carcinoma stemness

Purpose: Metastasis of hepatocellular carcinoma (HCC) critically impacts the survival prognosis of patients, with the pivotal role of hepatocellular carcinoma stem cells in initiating invasive metastatic behaviors. The Flap Endonuclease 1 (FEN1) is delineated as a metallonuclease, quintessential for...

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Bibliographic Details
Main Authors: Zhenxiang Peng, Shuling Wang, Diguang Wen, Zhechuan Mei, Hao Zhang, Shengtao Liao, Lin Lv, Chuanfei Li
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Translational Oncology
Subjects:
Flap Endonuclease 1
Stemness
Hepatocellular carcinoma
Small ubiquitin-related modifier 2
Online Access:http://www.sciencedirect.com/science/article/pii/S193652332400041X

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http://www.sciencedirect.com/science/article/pii/S193652332400041X

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