Construction of Dmd Gene Mutant Mice and Phenotype Verification in Muscle and Immune Systems

Construction of Dmd Gene Mutant Mice and Phenotype Verification in Muscle and Immune Systems

Objective The aim is to utilize CRISPR/Cas9 gene editing technology to construct Dmd gene mutant mice with a point mutation in exon 23 of the Dmd gene. Subsequently, the phenotypic changes of the mice in muscles and immune systems are analyzed and verified, providing an evaluation model for Duchenne...

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Bibliographic Details
Main Authors: LIANG Min, GUO Yang, WANG Jinjin, ZHU Mengyan, CHI Jun, CHEN Yanjuan, WANG Chengji, YU Zhilan, SHEN Ruling
Format: Article
Language:zho
Published: Editorial Office of Laboratory Animal and Comparative Medicine 2024-02-01
Series:Shiyan dongwu yu bijiao yixue
Subjects:
dmd gene
crispr/cas9
duchenne muscular dystrophy
c57bl/6j mice
Online Access:https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2023.089

Internet

https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2023.089

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