Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

Resistance to targeted cancer therapies is an important clinical problem. The discovery of anti-resistance drug combinations is challenging as resistance can arise by diverse escape mechanisms. To address this challenge, we improved and applied the experimental-computational perturbation biology met...

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Bibliographic Details
Main Authors: Anil Korkut, Weiqing Wang, Emek Demir, Bülent Arman Aksoy, Xiaohong Jing, Evan J Molinelli, Özgün Babur, Debra L Bemis, Selcuk Onur Sumer, David B Solit, Christine A Pratilas, Chris Sander
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-08-01
Series:eLife
Subjects:
network modeling
drug synergy
cancer drug resistance
proteomics
cellular signaling
melanoma
Online Access:https://elifesciences.org/articles/04640

Internet

https://elifesciences.org/articles/04640

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