Multi-trial analysis of HIV-1 envelope gp41-reactive antibodies among global recipients of candidate HIV-1 vaccines

Multi-trial analysis of HIV-1 envelope gp41-reactive antibodies among global recipients of candidate HIV-1 vaccines

Many participants in HIV-1 vaccine trials, who have not previously been exposed to or vaccinated against HIV-1, display serum immunoglobulin antibodies that bind the gp41 region of HIV-1 envelope prior to vaccination. Previous studies have hypothesized that these pre-existing antibodies may be cross...

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Bibliographic Details
Main Authors: Koshlan Mayer-Blackwell, Andrew M. Johnson, Nicole Potchen, Simon S. Minot, Jack Heptinstall, Kelly Seaton, Sheetal Sawant, Xiaoying Shen, Georgia D. Tomaras, Andrew Fiore-Gartland, James G. Kublin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
human immunodeficiency virus (HIV)
vaccines
antibody
microbiota
clinical trial
cross-reacting antibodies
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.983313/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.983313/full

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