Mapping of DNA methylation-sensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis

Mapping of DNA methylation-sensitive cellular processes in gingival and periodontal ligament fibroblasts in the context of periodontal tissue homeostasis

Interactions between gingival fibroblasts (GFs) and oral pathogens contribute to the chronicity of inflammation in periodontitis. Epigenetic changes in DNA methylation are involved in periodontitis pathogenesis, and recent studies indicate that DNA methyltransferase (DNMT) inhibitors may protect aga...

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Bibliographic Details
Main Authors: Katarzyna B. Lagosz-Cwik, Mariia Melnykova, Elwira Nieboga, Aureliusz Schuster, Agnieszka Bysiek, Slawomir Dudek, Weronika Lipska, Malgorzata Kantorowicz, Michal Tyrakowski, Dagmara Darczuk, Tomasz Kaczmarzyk, Marjolijn Gilijamse, Teun J. de Vries, Jan Potempa, Aleksander M. Grabiec
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
periodontitis
gingival fibroblast
periodontal ligament fibroblast
DNA methyltransferases
decitabine (DAC)
Porphyromonas gingivalis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1078031/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1078031/full

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