UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication.
Positive-strand RNA virus infections can induce the stress-related unfolded protein response (UPR) in host cells. This study found that enterovirus A71 (EVA71) utilizes host UDP-glucose glycoprotein glucosyltransferase 1 (UGGT1), a key endoplasmic reticulum protein (ER) involved in UPR, to enhance v...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-05-01
|
| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC5435352?pdf=render |