Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity

Shank2 Binds to aPKC and Controls Tight Junction Formation with Rap1 Signaling during Establishment of Epithelial Cell Polarity

Summary: Epithelial cells establish apicobasal polarity by forming tight junctions (TJs) at the apical-lateral boundary, which play fundamental roles in physiological functions. An evolutionarily conserved atypical protein kinase C (aPKC)-partitioning defective (PAR) complex functions as a platform...

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Bibliographic Details
Main Authors: Kazunori Sasaki, Noriko Kojitani, Hiroko Hirose, Yohei Yoshihama, Hidefumi Suzuki, Miho Shimada, Ayumi Takayanagi, Akio Yamashita, Masa-aki Nakaya, Hisashi Hirano, Hidehisa Takahashi, Shigeo Ohno
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472030262X

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http://www.sciencedirect.com/science/article/pii/S221112472030262X

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