First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor

First Discovery of Cholesterol-Lowering Activity of Parthenolide as NPC1L1 Inhibitor

Elevated cholesterol significantly increases the risk of developing atherosclerosis and coronary heart disease. The key to treating hypercholesterolemia is lowering plasma cholesterol levels. There have been no studies on the cholesterol-lowering potential of parthenolide (PTL), a naturally occurrin...

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Bibliographic Details
Main Authors: Wenjing Liu, Bing Liang, Jun Zeng, Jingsen Meng, Lingyu Shi, Shanbo Yang, Jing Chang, Chao Wang, Xiaokun Hu, Xufu Wang, Na Han, Chenghui Lu, Jiao Li, Congcong Wang, Huanting Li, Renshuai Zhang, Dongming Xing
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
cholesterol-lowering ability
PTL
NPC1L1
hypercholesterolemia
drug screening
Online Access:https://www.mdpi.com/1420-3049/27/19/6270

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https://www.mdpi.com/1420-3049/27/19/6270

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