5-Aza-2′-Deoxycytidine and Valproic Acid in Combination with CHIR99021 and A83-01 Induce Pluripotency Genes Expression in Human Adult Somatic Cells

5-Aza-2′-Deoxycytidine and Valproic Acid in Combination with CHIR99021 and A83-01 Induce Pluripotency Genes Expression in Human Adult Somatic Cells

A generation of induced pluripotent stem cells (iPSC) by ectopic expression of OCT4, SOX2, KLF4, and c-MYC has established promising opportunities for stem cell research, drug discovery, and disease modeling. While this forced genetic expression represents an advantage, there will always be an issue...

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Bibliographic Details
Main Authors: Alain Aguirre-Vázquez, Luis A. Salazar-Olivo, Xóchitl Flores-Ponce, Ana L. Arriaga-Guerrero, Dariela Garza-Rodríguez, María E. Camacho-Moll, Iván Velasco, Fabiola Castorena-Torres, Nidheesh Dadheech, Mario Bermúdez de León
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
reprogramming
5-aza-2′-deoxycytidine
valproic acid
stem cells
epigenetics
Online Access:https://www.mdpi.com/1420-3049/26/7/1909

Internet

https://www.mdpi.com/1420-3049/26/7/1909

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