Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors

Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors

Therapy of FLT3-positive acute myeloid leukemia still remains complicated, despite the availability of newly approved kinase inhibitors. Various strategies to avoid the reduced efficacy of therapy have been explored, including the development of dual targeting compounds, which inhibit FLT3 and anoth...

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Bibliographic Details
Main Authors: Monika Tomanová, Karolína Kozlanská, Radek Jorda, Lukáš Jedinák, Tereza Havlíková, Eva Řezníčková, Miroslav Peřina, Pavel Klener, Alexandra Dolníková, Petr Cankař, Vladimír Kryštof
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
FLT3
cyclin-dependent kinase
purine
inhibitor
acute myeloid leukemia
Online Access:https://www.mdpi.com/1422-0067/23/24/16169

Internet

https://www.mdpi.com/1422-0067/23/24/16169

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