Focal Cerebral Ischemia Induces Expression of Glutaminyl Cyclase along with Downstream Molecular and Cellular Inflammatory Responses

Focal Cerebral Ischemia Induces Expression of Glutaminyl Cyclase along with Downstream Molecular and Cellular Inflammatory Responses

Glutaminyl cyclase (QC) and its isoenzyme (isoQC) catalyze the formation of N-terminal pyroglutamate (pGlu) from glutamine on a number of neuropeptides, peptide hormones and chemokines. Chemokines of the C-C ligand (CCL) motif family are known to contribute to inflammation in neurodegenerative condi...

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Bibliographic Details
Main Authors: Corinna Höfling, Luise Ulrich, Sina Burghardt, Philippa Donkersloot, Michael Opitz, Stefanie Geissler, Stephan Schilling, Holger Cynis, Dominik Michalski, Steffen Roßner
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Cells
Subjects:
CCL2
experimental stroke
glutaminyl cyclase
microglia
astrocytes
Online Access:https://www.mdpi.com/2073-4409/13/17/1412

Internet

https://www.mdpi.com/2073-4409/13/17/1412

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