Bioinformatic validation and machine learning-based exploration of purine metabolism-related gene signatures in the context of immunotherapeutic strategies for nonspecific orbital inflammation

Bioinformatic validation and machine learning-based exploration of purine metabolism-related gene signatures in the context of immunotherapeutic strategies for nonspecific orbital inflammation

BackgroundNonspecific orbital inflammation (NSOI) represents a perplexing and persistent proliferative inflammatory disorder of idiopathic nature, characterized by a heterogeneous lymphoid infiltration within the orbital region. This condition, marked by the aberrant metabolic activities of its cell...

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Bibliographic Details
Main Authors: Zixuan Wu, Chi Fang, Yi Hu, Xin Peng, Zheyuan Zhang, Xiaolei Yao, Qinghua Peng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
nonspecific orbital inflammation (NSOI)
purine metabolism genes (PMGs)
LASSO regression
SVM-RFE
bioinformatics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1318316/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1318316/full

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