Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments

Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments

S100 proteins assume a diversity of oligomeric states including large order self-assemblies, with an impact on protein structure and function. Previous work has uncovered that S100 proteins, including S100B, are prone to undergo β-aggregation under destabilizing conditions. This propensity is encode...

Full description

Bibliographic Details
Main Authors: Joana S. Cristóvão, Mariana A. Romão, Rodrigo Gallardo, Joost Schymkowitz, Frederic Rousseau, Cláudio M. Gomes
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Molecules
Subjects:
S100 proteins
protein aggregation
amyloid
protein biophysics
structural biology
Online Access:https://www.mdpi.com/1420-3049/26/2/440

Internet

https://www.mdpi.com/1420-3049/26/2/440

Similar Items