Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium

Harmonization and qualification of an IFN-γ Enzyme-Linked ImmunoSpot assay (ELISPOT) to measure influenza-specific cell-mediated immunity within the FLUCOP consortium

Influenza continues to be the most important cause of viral respiratory disease, despite the availability of vaccines. Today’s evaluation of influenza vaccines mainly focuses on the quantitative and functional analyses of antibodies to the surface proteins haemagglutinin (HA) and neuraminidase (NA)....

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Bibliographic Details
Main Authors: Gwenn Waerlop, Geert Leroux-Roels, Teresa Lambe, Duncan Bellamy, Donata Medaglini, Elena Pettini, Rebecca Jane Cox, Mai-Chi Trieu, Richard Davies, Geir Bredholt, Emanuele Montomoli, Elena Gianchecchi, Frédéric Clement
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
IFN-γ ELISpot
cell-mediated immunity
assay qualification
assay harmonization
influenza
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.984642/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.984642/full

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