Electrochemical oxidation of allylic CH bond for α, β-unsaturated ketones without peroxide
α,β-Unsaturated ketone is one of the important building blocks of the plenty of alkaloids, spices and pharmaceutical agents. Herein, we describe a peroxide-free electrochemical strategy to realize site-selective allylic C − H oxidation for the synthesis of α,β-unsaturated ketones. This electrochemic...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-07-01
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Series: | Journal of Saudi Chemical Society |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610323000777 |
Summary: | α,β-Unsaturated ketone is one of the important building blocks of the plenty of alkaloids, spices and pharmaceutical agents. Herein, we describe a peroxide-free electrochemical strategy to realize site-selective allylic C − H oxidation for the synthesis of α,β-unsaturated ketones. This electrochemically driven oxidation exhibits a broad substrate scope. Mechanistic investigations of this reaction uncovered HOAc and H2O as the oxygen source to achieve peroxide-free electrochemical allylic C − H oxidation. |
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ISSN: | 1319-6103 |