Decoding Macrophage Subtypes to Engineer Modulating Hydrogels for the Alleviation of Intervertebral Disk Degeneration

Decoding Macrophage Subtypes to Engineer Modulating Hydrogels for the Alleviation of Intervertebral Disk Degeneration

Abstract A major pathological basis for low back pain is intervertebral disk degeneration, which is primarily caused by the degeneration of nucleus pulposus cells due to imbalances in extracellular matrix (ECM) anabolism and catabolism. The phenotype of macrophages in the local immune microenvironme...

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Bibliographic Details
Main Authors: Da‐Wang Zhao, Qian Cheng, Huimin Geng, Jinbo Liu, Yuanqiang Zhang, Jiwei Cui, Chao Liu, Lei Cheng
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Advanced Science
Subjects:
hydroxyapatite nanorods
intervertebral disk degeneration
macrophage polarization
polymer hydrogels
polyphenol
Online Access:https://doi.org/10.1002/advs.202304480

Internet

https://doi.org/10.1002/advs.202304480

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