The NK-1 Receptor Antagonist L-732,138 Induces Apoptosis and Counteracts Substance P-Related Mitogenesis in Human Melanoma Cell Lines

It has been recently demonstrated that substance P (SP) and neurokinin-1 (NK-1) receptor antagonists induce cell proliferation and cell inhibition in human melanoma cells, respectively. However, the antitumor action of the NK-1 receptor antagonist L-732,138 on such cells is unknown. The aim of this...

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Bibliographic Details
Main Authors: Miguel Muñoz, Marisa Rosso, Ana González-Ortega, Rafael Coveñas
Format: Article
Language:English
Published: MDPI AG 2010-04-01
Series:Cancers
Subjects:
Online Access:http://www.mdpi.com/2072-6694/2/2/611/