H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

Summary: Cancer-associated mutations in genes encoding histones dramatically reshape chromatin and support tumorigenesis. Lysine to methionine substitution of residue 27 on histone H3 (K27M) is a driver mutation in high-grade pediatric gliomas, known to abrogate polycomb repressive complex 2 (PRC2)...

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Bibliographic Details
Main Authors: Noa Furth, Danielle Algranati, Bareket Dassa, Olga Beresh, Vadim Fedyuk, Natasha Morris, Lawryn H. Kasper, Dan Jones, Michelle Monje, Suzanne J. Baker, Efrat Shema
Format: Article
Language:English
Published: Elsevier 2022-05-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472200609X

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http://www.sciencedirect.com/science/article/pii/S221112472200609X

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