Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development

Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development

The authors identify Nuclear receptor subfamily 6 group A member 1 (Nr6a1) as a master regulator of elongation, segmentation, patterning and lineage allocation specifically within the trunk region of the mouse, acting downstream of the major signals known to control vertebral column formation.

Библиографические подробности
Главные авторы:	Yi-Cheng Chang, Jan Manent, Jan Schroeder, Siew Fen Lisa Wong, Gabriel M. Hauswirth, Natalia A. Shylo, Emma L. Moore, Annita Achilleos, Victoria Garside, Jose M. Polo, Paul Trainor, Edwina McGlinn
Формат:	Статья
Язык:	English
Опубликовано:	Nature Portfolio 2022-12-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-022-35303-4

Схожие документы

Editorial: Mechanisms of hox-driven patterning and morphogenesis
по: Marie Kmita, и др.
Опубликовано: (2022-09-01)

A Hox Code Defines Spinocerebellar Neuron Subtype Regionalization
по: Eamon Coughlan, и др.
Опубликовано: (2019-11-01)

The expanding roles of Nr6a1 in development and evolution
по: Jingxuan Li, и др.
Опубликовано: (2024-02-01)

Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo
по: Natalia Benetti, и др.
Опубликовано: (2022-07-01)

In ovo application of antagomiRs indicates a role for miR-196 in patterning the chick axial skeleton through Hox gene regulation
по: McGlinn, Edwina, и др.
Опубликовано: (2010)

Breaking constraint of mammalian axial formulae
по: Gabriel M. Hauswirth, и др.
Опубликовано: (2022-01-01)

Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs
по: Wong, Siew Fen Lisa, и др.
Опубликовано: (2016)

Collinear Hox-Hox interactions are involved in patterning the vertebrate anteroposterior (A-P) axis.
по: Kongju Zhu, и др.
Опубликовано: (2017-01-01)

Two Tier Hox Collinearity Mediates Vertebrate Axial Patterning
по: Antony J. Durston
Опубликовано: (2018-09-01)

Making Headway: The Roles of Hox Genes and Neural Crest Cells in Craniofacial Development
по: Paul A. Trainor
Опубликовано: (2003-01-01)

A degenerate ParaHox gene cluster in a degenerate vertebrate.
по: Furlong, R, и др.
Опубликовано: (2007)

Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers.
по: Parker, H, и др.
Опубликовано: (2011)

Hox genes control vertebrate body elongation by collinear Wnt repression
по: Nicolas Denans, и др.
Опубликовано: (2015-02-01)

Ancient Pbx-Hox signatures define hundreds of vertebrate developmental enhancers
по: Parker Hugo J, и др.
Опубликовано: (2011-12-01)

Extreme conservation of noncoding DNA near <it>HoxD </it>complex of vertebrates
по: Tripathi Anshuman, и др.
Опубликовано: (2004-10-01)

Multiple chromosomal rearrangements structured the ancestral vertebrate Hox-bearing protochromosomes.
по: Vincent J Lynch, и др.
Опубликовано: (2009-01-01)

Revisiting the origin of the vertebrate Hox14 by including its relict sarcopterygian members.
по: Feiner, N, и др.
Опубликовано: (2011)

Hox genes in the coordination of embryonic development. Model of hourglass in the description of vertebrate ontogenesis
по: Sergey Dolomatov, и др.
Опубликовано: (2021-12-01)

A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates
по: Hugo J. Parker, и др.
Опубликовано: (2019-03-01)

Deep time perspective on turtle neck evolution: chasing the Hox code by vertebral morphology
по: Christine Böhmer, и др.
Опубликовано: (2017-08-01)

Some Questions and Answers About the Role of Hox Temporal Collinearity in Vertebrate Axial Patterning
по: Antony J. Durston
Опубликовано: (2019-11-01)

Examining the assumptions of heterogeneity-based management for promoting plant diversity in a disturbance-prone ecosystem
по: Daniel J. McGlinn, и др.
Опубликовано: (2019-05-01)

Spatial Structure Alters the Shape of the Unimodal Species Richness-Biomass Relationship in a Neutral Model
по: Daniel J. McGlinn, и др.
Опубликовано: (2010-04-01)

Prevention of Treacher Collins syndrome craniofacial anomalies in mouse models via maternal antioxidant supplementation
по: Daisuke Sakai, и др.
Опубликовано: (2016-01-01)

Evolution of the head-trunk interface in tetrapod vertebrates
по: Elizabeth M Sefton, и др.
Опубликовано: (2016-04-01)

Correlation between Hox code and vertebral morphology in the mouse: towards a universal model for Synapsida
по: Christine Böhmer
Опубликовано: (2017-06-01)

MicroRNA governs bistable cell differentiation and lineage segregation via a noncanonical feedback
по: Chung‐Jung Li, и др.
Опубликовано: (2021-04-01)

Two more Posterior Hox genes and Hox cluster dispersal in echinoderms
по: Réka Szabó, и др.
Опубликовано: (2018-12-01)

An empirical evaluation of four variants of a universal species–area relationship
по: Daniel J. McGlinn, и др.
Опубликовано: (2013-11-01)

Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos
по: Yu-Sheng Hung, и др.
Опубликовано: (2024-12-01)

Extensive polycistronism and antisense transcription in the mammalian Hox clusters.
по: Gaëll Mainguy, и др.
Опубликовано: (2007-04-01)

HOX gene expression /
по: 180263 Papageorgiou, Spyros
Опубликовано: (2007)

Comparative analyses of vertebrate posterior <it>HoxD </it>clusters reveal atypical cluster architecture in the caecilian <it>Typhlonectes natans</it>
по: Amemiya Chris T, и др.
Опубликовано: (2010-11-01)

HoxPred: automated classification of Hox proteins using combinations of generalised profiles
по: Leyns Luc, и др.
Опубликовано: (2007-07-01)

Of Necks, Trunks and Tails: Axial Skeletal Diversity among Vertebrates
по: Moisés Mallo
Опубликовано: (2021-06-01)

Trunk muscle activity is modified in osteoporotic vertebral fracture and thoracic kyphosis with potential consequences for vertebral health.
по: Alison M Greig, и др.
Опубликовано: (2014-01-01)

The Trox-2 Hox/ParaHox gene of Trichoplax (Placozoa) marks an epithelial boundary.
по: Jakob, W, и др.
Опубликовано: (2004)

Genomic and transcriptomic survey of bryozoan Hox and ParaHox genes with emphasis on phylactolaemate bryozoans
по: Ahmed J. Saadi, и др.
Опубликовано: (2023-11-01)

A single three-dimensional chromatin compartment in amphioxus indicates a stepwise evolution of vertebrate Hox bimodal regulation
по: Acemel, R, и др.
Опубликовано: (2016)

Abnormal origin of the vertebral arteries with Bicarotid trunk: a case report
по: Ömer Faruk Topaloğlu, и др.
Опубликовано: (2022-04-01)