High throughput screening of mesenchymal stromal cell morphological response to inflammatory signals for bioreactor-based manufacturing of extracellular vesicles that modulate microglia

High throughput screening of mesenchymal stromal cell morphological response to inflammatory signals for bioreactor-based manufacturing of extracellular vesicles that modulate microglia

Due to their immunomodulatory function, mesenchymal stromal cells (MSCs) are a promising therapeutic with the potential to treat neuroinflammation associated with neurodegenerative diseases. This function is mediated by secreted extracellular vesicles (MSC-EVs). Despite established safety, MSC clini...

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Bibliographic Details
Main Authors: Andrew M. Larey, Thomas M. Spoerer, Kanupriya R. Daga, Maria G. Morfin, Hannah M. Hynds, Jana Carpenter, Kelly M. Hines, Ross A. Marklein
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-07-01
Series:Bioactive Materials
Subjects:
Mesenchymal stromal cell
High throughput screening
Extracellular vesicle
Bioreactor
Microglia
Lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X24000902

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http://www.sciencedirect.com/science/article/pii/S2452199X24000902

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