TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic β1-integrin

TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic β1-integrin

Background Astrocytes regulate blood-brain barrier (BBB) integrity, whereas subarachnoid haemorrhage (SAH) results in astrocyte dysregulation and BBB disruption. Here, we explored the involvement of tissue inhibitor of matrix metalloprotease-1 (TIMP1) in astrocyte-mediated BBB protection during SAH,...

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Bibliographic Details
Main Authors: Jing Liu, Huaijun Chen, Gao Chen, Hang Zhou, Cong Qian, Tianchi Tang, Linfeng Fan, Libin Hu, Jingya Ye, Chaohui Jing, Chaoran Xu, Xinyan Wu, Yike Chen, Zihang Chen, Xiongjie Fu, Jingsen Chen, Zhongju Tan, Hanhai Zeng, Fuyi Liu
Format: Article
Language:English
Published: BMJ Publishing Group
Series:Stroke and Vascular Neurology
Online Access:https://svn.bmj.com/content/early/2024/03/14/svn-2023-002956.full

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https://svn.bmj.com/content/early/2024/03/14/svn-2023-002956.full

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